Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway

Ewing sarcoma (ES) is a bone and soft tissue sarcoma affecting mostly children and young adults. Caveolin-1 (CAV1) is a well-known target of EWS/FLI1, the main driver of ES, with an oncogenic role in ES. We have previously described how CAV1 is able to induce metastasis in ES via matrix metalloprote...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Lagares-Tena, Laura, García-Monclús, Silvia, López-Alemany, Roser, Almacellas-Rabaiget, Olga, Huertas-Martínez, Juan, Sáinz-Jaspeado, Miguel, Mateo-Lozano, Silvia, Rodríguez-Galindo, Carlos, Rello-Varona, Santiago, Herrero-Martín, David, Tirado, Oscar M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302960/
https://ncbi.nlm.nih.gov/pubmed/27487136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10872
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