Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing

Despite significant improvement in treatment of childhood acute myeloid leukemia (AML), 30% of patients experience disease recurrence, which is still the major cause of treatment failure and death in these patients. To investigate molecular mechanisms underlying relapse, we performed whole-exome seq...

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Udgivet i:Oncotarget
Main Authors: Masetti, Riccardo, Castelli, Ilaria, Astolfi, Annalisa, Bertuccio, Salvatore Nicola, Indio, Valentina, Togni, Marco, Belotti, Tamara, Serravalle, Salvatore, Tarantino, Giuseppe, Zecca, Marco, Pigazzi, Martina, Basso, Giuseppe, Pession, Andrea, Locatelli, Franco
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302950/
https://ncbi.nlm.nih.gov/pubmed/27462774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10778
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