Inhibition of Methyltransferase DOT1L Sensitizes to Sorafenib Treatment AML Cells Irrespective of MLL-Rearrangements: A Novel Therapeutic Strategy for Pediatric AML

Pediatric acute myeloid leukemia (AML) is an aggressive malignancy with poor prognosis for which there are few effective targeted approaches, despite the numerous genetic alterations, including MLL gene rearrangements (MLL-r). The histone methyltransferase DOT1L is involved in supporting the prolife...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancers (Basel)
Egile Nagusiak: Lonetti, Annalisa, Indio, Valentina, Laginestra, Maria Antonella, Tarantino, Giuseppe, Chiarini, Francesca, Astolfi, Annalisa, Bertuccio, Salvatore N., Martelli, Alberto M., Locatelli, Franco, Pession, Andrea, Masetti, Riccardo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7409321/
https://ncbi.nlm.nih.gov/pubmed/32698374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12071972
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