Pregnane X-receptor promotes stem cell-mediated colon cancer relapse

Colorectal cancer lethality usually results from post-treatment relapse in the majority of stage II-IV patients, due to the enhanced resistance of Cancer Stem Cells (CSCs). Here, we show that the nuclear receptor Pregnane X Receptor (PXR, NR1I2), behaves as a key driver of CSC-mediated tumor recurre...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Planque, Chris, Rajabi, Fatemeh, Grillet, Fanny, Finetti, Pascal, Bertucci, François, Gironella, Meritxell, Lozano, Juan José, Beucher, Bertrand, Giraud, Julie, Garambois, Véronique, Vincent, Charles, Brown, Daniel, Caillo, Ludovic, Kantar, Jovana, Pelegrin, André, Prudhomme, Michel, Ripoche, Jérémie, Bourgaux, Jean François, Ginestier, Christophe, Castells, Antoni, Hollande, Frédéric, Pannequin, Julie, Pascussi, Jean Marc
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302934/
https://ncbi.nlm.nih.gov/pubmed/27448961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10646
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