Pregnane X-receptor promotes stem cell-mediated colon cancer relapse

Colorectal cancer lethality usually results from post-treatment relapse in the majority of stage II-IV patients, due to the enhanced resistance of Cancer Stem Cells (CSCs). Here, we show that the nuclear receptor Pregnane X Receptor (PXR, NR1I2), behaves as a key driver of CSC-mediated tumor recurre...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Planque, Chris, Rajabi, Fatemeh, Grillet, Fanny, Finetti, Pascal, Bertucci, François, Gironella, Meritxell, Lozano, Juan José, Beucher, Bertrand, Giraud, Julie, Garambois, Véronique, Vincent, Charles, Brown, Daniel, Caillo, Ludovic, Kantar, Jovana, Pelegrin, André, Prudhomme, Michel, Ripoche, Jérémie, Bourgaux, Jean François, Ginestier, Christophe, Castells, Antoni, Hollande, Frédéric, Pannequin, Julie, Pascussi, Jean Marc
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302934/
https://ncbi.nlm.nih.gov/pubmed/27448961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10646
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