XIAP RING domain mediates miR-4295 expression and subsequently inhibiting p63α protein translation and promoting transformation of bladder epithelial cells

The X-linked inhibitor of apoptosis protein (XIAP) contains three N-terminal BIR domains that mediate anti-apoptosis and one C-terminal RING finger domain whose function(s) are not fully defined. Here we show that the RING domain of XIAP strongly inhibits the expression of p63α, a known tumor suppre...

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Vydáno v:Oncotarget
Hlavní autoři: Jin, Honglei, Xu, Jiheng, Guo, Xirui, Huang, Haishan, Li, Jingxia, Peng, Minggang, Zhu, Junlan, Tian, Zhongxian, Wu, Xue-Ru, Tang, Moon-Shong, Huang, Chuanshu
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302933/
https://ncbi.nlm.nih.gov/pubmed/27447744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10645
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