Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma

P-glycoprotein (P-gp) overexpression is associated with poor prognosis and drug-resistance in osteosarcoma (OS), but the underlying mechanisms remain incompletely understood. Here, we examined the regulation of P-gp, GRP78, and phospho-Akt in doxorubicin (DOX)-treated OS cells. DOX induced P-gp expr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Xia, Yuan-Zheng, Yang, Lei, Xue, Gui-Min, Zhang, Chao, Guo, Chao, Yang, Yan-Wei, Li, Shan-Shan, Zhang, Lu-Yong, Guo, Qing-Long, Kong, Ling-Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302920/
https://ncbi.nlm.nih.gov/pubmed/27486760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10890
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