An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

MicroRNAs (miRNAs) perform critical functions in normal physiology and disease by associating with Argonaute proteins and downregulating partially complementary messenger RNAs (mRNAs). To identify new regulators of the miRNA pathway, we employed CRISPR-Cas9 genome-wide loss-of-function screening cou...

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Bibliographic Details
Published in:Nature
Main Authors: Golden, Ryan J., Chen, Beibei, Li, Tuo, Braun, Juliane, Manjunath, Hema, Chen, Xiang, Wu, Jiaxi, Schmid, Vanessa, Chang, Tsung-Cheng, Kopp, Florian, Ramirez-Martinez, Andres, Tagliabracci, Vincent S., Chen, Zhijian J., Xie, Yang, Mendell, Joshua T.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302127/
https://ncbi.nlm.nih.gov/pubmed/28114302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21025
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