Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear

OBJECTIVES: Rotator cuff tears are among the most frequent upper extremity injuries. Current treatment strategies do not address the poor quality of the muscle and tendon following chronic rotator cuff tears. Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that activates many gen...

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Bibliographic Details
Published in:Bone Joint Res
Main Authors: Gumucio, J. P., Flood, M. D., Bedi, A., Kramer, H. F., Russell, A. J., Mendias, C. L.
Format: Artigo
Language:Inglês
Published: 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301902/
https://ncbi.nlm.nih.gov/pubmed/28108482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1302/2046-3758.61.BJR-2016-0232.R1
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