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Engineering the residual side chains of HAP phytases to improve their pepsin resistance and catalytic efficiency

Strong resistance to proteolytic attack is important for feed enzymes. Here, we selected three predicted pepsin cleavage sites, L99, L162, and E230 (numbering from the initiator M of premature proteins), in pepsin-sensitive HAP phytases YkAPPA from Yersinia kristensenii and YeAPPA from Y. enterocoli...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Niu, Canfang, Yang, Peilong, Luo, Huiying, Huang, Huoqing, Wang, Yaru, Yao, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301473/
https://ncbi.nlm.nih.gov/pubmed/28186144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42133
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