Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells

BACKGROUND: Systemic sclerosis (SSc) is characterized by endothelial cell (EC) apoptosis, impaired angiogenesis and peripheral microvasculopathy. Soluble α-Klotho (sKl) is a pleiotropic molecule with multiple effects on ECs, including antioxidant and vasculoprotective activities. On the EC surface,...

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Bibliografski detalji
Izdano u:Arthritis Res Ther
Glavni autori: Mazzotta, Celestina, Manetti, Mirko, Rosa, Irene, Romano, Eloisa, Blagojevic, Jelena, Bellando-Randone, Silvia, Bruni, Cosimo, Lepri, Gemma, Guiducci, Serena, Ibba-Manneschi, Lidia, Matucci-Cerinic, Marco
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301388/
https://ncbi.nlm.nih.gov/pubmed/28183357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1233-0
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