RNAi-mediated knockdown of mouse melanocortin-4 receptor in vitro and in vivo, using an siRNA expression construct based on the mir-187 precursor

RNA interference (RNAi) is a powerful tool for the study of gene function in mammalian systems, including transgenic mice. Here, we report a gene knockdown system based on the human mir-187 precursor. We introduced small interfering RNA (siRNA) sequences against the mouse melanocortin-4 receptor (mM...

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Detalhes bibliográficos
Publicado no:Exp Anim
Main Authors: Kato, Minoru, Huang, Yi-Ying, Matsuo, Mina, Takashina, Yoko, Sasaki, Kazuyo, Horai, Yasushi, Juni, Aya, Kamijo, Shin-Ichi, Saigo, Kaoru, Ui-Tei, Kumiko, Tei, Hajime
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Association for Laboratory Animal Science 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301000/
https://ncbi.nlm.nih.gov/pubmed/27725374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.16-0065
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