Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells.

A gene-targeting construct was made containing 7.8 kilobases of DNA spanning exon 10 of the mouse cystic fibrosis transmembrane regulator (CFTR) gene in which part of the exon has been replaced by two neomycin-resistance (Neo) genes driven by different promoters. (This replacement introduces a chain...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Koller, B H, Kim, H S, Latour, A M, Brigman, K, Boucher, R C, Scambler, P, Wainwright, B, Smithies, O
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53004/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1720548/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.23.10730
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