Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells.

A gene-targeting construct was made containing 7.8 kilobases of DNA spanning exon 10 of the mouse cystic fibrosis transmembrane regulator (CFTR) gene in which part of the exon has been replaced by two neomycin-resistance (Neo) genes driven by different promoters. (This replacement introduces a chain...

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Библиографические подробности
Главные авторы: Koller, B H, Kim, H S, Latour, A M, Brigman, K, Boucher, R C, Scambler, P, Wainwright, B, Smithies, O
Формат: Artigo
Язык:Inglês
Опубликовано: 1991
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC53004/
https://ncbi.nlm.nih.gov/pubmed/1720548
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