Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system

Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent transcription factor involved in many aspects of metabolism, immune response, and development. Total-body deletion of the two Pparg alleles provoked generalized lipoatrophy along with severe type 2 diabetes. Herein, we explor...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Toffoli, Barbara, Gilardi, Federica, Winkler, Carine, Soderberg, Magnus, Kowalczuk, Laura, Arsenijevic, Yvan, Bamberg, Krister, Bonny, Olivier, Desvergne, Béatrice
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300244/
https://ncbi.nlm.nih.gov/pubmed/28182703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171474
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