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Self-correcting mismatches during high-fidelity DNA replication

Faithfull DNA replication is essential to all forms of life and depends on the action of 3'-5' exonucleases that remove misincorporated nucleotides from the newly synthesized strand. However, how the DNA is transferred from the polymerase to exonuclease active site is not known. Here we pr...

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Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Fernandez-Leiro, Rafael, Conrad, Julian, Yang, Ji-Chun, Freund, Stefan M. V., Scheres, Sjors H. W., Lamers, Meindert H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300136/
https://ncbi.nlm.nih.gov/pubmed/28067916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3348
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