Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials

Key disparities between the timing and methods of assessment in animal stroke studies and clinical trial may be part of the reason for the failure to translate promising findings. This study investigates the development of ischemic damage after thread occlusion MCAo in the rat, using histological an...

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Publicat a:PLoS One
Autors principals: Rewell, Sarah S. J., Churilov, Leonid, Sidon, T. Kate, Aleksoska, Elena, Cox, Susan F., Macleod, Malcolm R., Howells, David W.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300105/
https://ncbi.nlm.nih.gov/pubmed/28182727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171688
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