Surface Accessibility and Dynamics of Macromolecular Assemblies Probed by Covalent Labeling Mass Spectrometry and Integrative Modeling

[Image: see text] Mass spectrometry (MS) has become an indispensable tool for investigating the architectures and dynamics of macromolecular assemblies. Here we show that covalent labeling of solvent accessible residues followed by their MS-based identification yields modeling restraints that allow...

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Vydáno v:Anal Chem
Hlavní autoři: Schmidt, Carla, Macpherson, Jamie A., Lau, Andy M., Tan, Ken Wei, Fraternali, Franca, Politis, Argyris
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2017
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299547/
https://ncbi.nlm.nih.gov/pubmed/28208298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b02875
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