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Synthesis and opioid receptor binding of indium (III) and [(111)In]-labeled macrocyclic conjugates of diprenorphine: novel ligands designed for imaging studies of peripheral opioid receptors

Radiolabeled diprenorphine (DPN) and analogs are widely used ligands for non-invasive brain imaging of opioid receptors. To develop complementary radioligands optimized for studies of the peripheral opioid receptors, we prepared a pair of hydrophilic DPN derivatives, conjugated to the macrocyclic ch...

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Publicat a:Tetrahedron
Autors principals: Srivastava, Shefali, Fergason-Cantrell, Emily A., Nahas, Roger I., Lever, John R.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5298243/
https://ncbi.nlm.nih.gov/pubmed/28190898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2016.08.015
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