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Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry

The first total synthesis of malagashanine, a chloroquine potentiating indole alkaloid, is presented. A highly stereoselective cascade annulation reaction was developed to generate the tetracyclic core of the Malagasy alkaloids. This chemistry is likely to be broadly applicable to the synthesis of o...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Kong, A., Mancheno, D. E., Boudet, N., Delgado, R., Andreansky, E. S., Blakey, S. B.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297967/
https://ncbi.nlm.nih.gov/pubmed/28451219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc03578g
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