Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein.

The c-fos gene product Fos has been implicated in many cellular processes, including signal transduction, DNA synthesis, and resistance to antineoplastic agents. A fos ribozyme (catalytic RNA) was designed to evaluate the effects of suppressing Fos protein synthesis on expression of enzymes involved...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Scanlon, K J, Jiao, L, Funato, T, Wang, W, Tone, T, Rossi, J J, Kashani-Sabet, M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52975/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1660142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.23.10591
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