Defining CD8(+) T cells that provide the proliferative burst after PD-1 therapy

Chronic viral infections are characterized by a state of CD8(+) T-cell dysfunction that is associated with expression of the programmed cell death 1 (PD-1) inhibitory receptor(1–4). A better understanding of the mechanisms that regulate CD8(+) T cell responses during chronic infection is required to...

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Publicado no:Nature
Main Authors: Im, Se Jin, Hashimoto, Masao, Gerner, Michael Y., Lee, Junghwa, Kissick, Haydn T., Burger, Matheus C., Shan, Qiang, Hale, J. Scott, Lee, Judong, Nasti, Tahseen H., Sharpe, Arlene H., Freeman, Gordon J., Germain, Ronald N., Nakaya, Helder I., Xue, Hai-Hui, Ahmed, Rafi
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297183/
https://ncbi.nlm.nih.gov/pubmed/27501248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19330
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