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β Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants

The human ventricular cardiomyocyte transient outward K(+) current (I(to)) mediates the initial phase of myocyte repolarization and its disruption is implicated in Brugada Syndrome and heart failure (HF). Human cardiac I(to) is generated primarily by two Kv4.3 splice variants (Kv4.3L and Kv4.3S, div...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Physiol
Prif Awdur: Abbott, Geoffrey W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296356/
https://ncbi.nlm.nih.gov/pubmed/28228734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00066
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