Agonistic Anti-PDGF Receptor Autoantibodies from Patients with Systemic Sclerosis Impact Human Pulmonary Artery Smooth Muscle Cells Function In Vitro

One of the earliest events in the pathogenesis of systemic sclerosis (SSc) is microvasculature damage with intimal hyperplasia and accumulation of cells expressing PDGF receptor. Stimulatory autoantibodies targeting PDGF receptor have been detected in SSc patients and demonstrated to induce fibrosis...

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Vydáno v:Front Immunol
Hlavní autoři: Svegliati, Silvia, Amico, Donatella, Spadoni, Tatiana, Fischetti, Colomba, Finke, Doreen, Moroncini, Gianluca, Paolini, Chiara, Tonnini, Cecilia, Grieco, Antonella, Rovinelli, Marina, Funaro, Ada, Gabrielli, Armando
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296309/
https://ncbi.nlm.nih.gov/pubmed/28228756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00075
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