Agonistic Anti-PDGF Receptor Autoantibodies from Patients with Systemic Sclerosis Impact Human Pulmonary Artery Smooth Muscle Cells Function In Vitro

One of the earliest events in the pathogenesis of systemic sclerosis (SSc) is microvasculature damage with intimal hyperplasia and accumulation of cells expressing PDGF receptor. Stimulatory autoantibodies targeting PDGF receptor have been detected in SSc patients and demonstrated to induce fibrosis...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Svegliati, Silvia, Amico, Donatella, Spadoni, Tatiana, Fischetti, Colomba, Finke, Doreen, Moroncini, Gianluca, Paolini, Chiara, Tonnini, Cecilia, Grieco, Antonella, Rovinelli, Marina, Funaro, Ada, Gabrielli, Armando
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296309/
https://ncbi.nlm.nih.gov/pubmed/28228756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00075
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