Nur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression

Nur77, an orphan member of the nuclear receptor superfamily, plays critical roles in inflammation and immunity. However, the role of Nur77 in tumor microenvironment remains elusive. Results showed that deletion of Nur77 strikingly enhanced tumor metastasis compared to WT mice. Additionally, compared...

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Veröffentlicht in:PLoS One
Hauptverfasser: Li, Xiu-Ming, Wang, Jing-Ru, Shen, Tong, Gao, Shang-Shang, He, Xiao-Shun, Li, Jiang-Nan, Yang, Tian-Yu, Zhang, Shen, Gan, Wen-Juan, Li, Jian-Ming, Wu, Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295676/
https://ncbi.nlm.nih.gov/pubmed/28170411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171347
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