Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging

Dysfunction of neuronal activity is a major and early contributor to cognitive impairment in Alzheimer's disease (AD). To investigate neuronal activity alterations at early stage of AD, we encompassed behavioral testing and in vivo manganese-enhanced magnetic resonance imaging (MEMRI) in 5XFAD...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tang, Xiang, Wu, Di, Gu, Li-Hua, Nie, Bin-Bin, Qi, Xin-Yang, Wang, Yan-Juan, Wu, Fang-Fang, Li, Xiao-Li, Bai, Feng, Chen, Xiao-Chun, Xu, Lin, Ren, Qing-Guo, Zhang, Zhi-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295372/
https://ncbi.nlm.nih.gov/pubmed/27542275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11353
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