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Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies

BACKGROUND: We analyzed placental DNA methylation levels at repeated sequences (LINE1 elements) and all CCGG sites (the LUMA assay) to study the effect of modifiable clinical or laboratory procedures involved in in vitro fertilization. We included four potential modifiable factors: oxygen tension du...

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Bibliografiske detaljer
Udgivet i:Clin Epigenetics
Main Authors: Ghosh, Jayashri, Coutifaris, Christos, Sapienza, Carmen, Mainigi, Monica
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295214/
https://ncbi.nlm.nih.gov/pubmed/28191261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0318-6
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