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Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies

BACKGROUND: We analyzed placental DNA methylation levels at repeated sequences (LINE1 elements) and all CCGG sites (the LUMA assay) to study the effect of modifiable clinical or laboratory procedures involved in in vitro fertilization. We included four potential modifiable factors: oxygen tension du...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Epigenetics
Hauptverfasser: Ghosh, Jayashri, Coutifaris, Christos, Sapienza, Carmen, Mainigi, Monica
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295214/
https://ncbi.nlm.nih.gov/pubmed/28191261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0318-6
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