Lipin-2 regulates NLRP3 inflammasome by affecting P2X(7) receptor activation

Mutations in human LPIN2 produce a disease known as Majeed syndrome, the clinical manifestations of which are ameliorated by strategies that block IL-1β or its receptor. However the role of lipin-2 during IL-1β production remains elusive. We show here that lipin-2 controls excessive IL-1β formation...

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Bibliographische Detailangaben
Veröffentlicht in:J Exp Med
Hauptverfasser: Lordén, Gema, Sanjuán-García, Itziar, de Pablo, Nagore, Meana, Clara, Alvarez-Miguel, Inés, Pérez-García, M. Teresa, Pelegrín, Pablo, Balsinde, Jesús, Balboa, María A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294860/
https://ncbi.nlm.nih.gov/pubmed/28031477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161452
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