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Systematic Approach for the Formulation and Optimization of Solid Lipid Nanoparticles of Efavirenz by High Pressure Homogenization Using Design of Experiments for Brain Targeting and Enhanced Bioavailability

The nonnucleoside reverse transcriptase inhibitors, used for the treatment of HIV infections, are reported to have low bioavailability pertaining to high first-pass metabolism, high protein binding, and enzymatic metabolism. They also show low permeability across blood brain barrier. The CNS is repo...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Gupta, Shweta, Kesarla, Rajesh, Chotai, Narendra, Misra, Ambikanandan, Omri, Abdelwahab
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294220/
https://ncbi.nlm.nih.gov/pubmed/28243600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5984014
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