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Early commitment and robust differentiation in colonic crypts

Tissue stem cells produce a constant flux of differentiated cells with distinct proportions. Here, we show that stem cells in colonic crypts differentiate early to form precisely 1:3 ratio of secretory to absorptive cells. This precision is surprising, as there are only eight stem cells making irrev...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Tóth, Beáta, Ben‐Moshe, Shani, Gavish, Avishai, Barkai, Naama, Itzkovitz, Shalev
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293156/
https://ncbi.nlm.nih.gov/pubmed/28049136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20167283
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