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One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen
Many promising vaccine candidates from pathogenic viruses, bacteria, and parasites are unstable and cannot be produced cheaply for clinical use. For instance, Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is essential for erythrocyte invasion, is highly conserved among field i...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5293100/ https://ncbi.nlm.nih.gov/pubmed/28096331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616903114 |
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