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One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen

Many promising vaccine candidates from pathogenic viruses, bacteria, and parasites are unstable and cannot be produced cheaply for clinical use. For instance, Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is essential for erythrocyte invasion, is highly conserved among field i...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Campeotto, Ivan, Goldenzweig, Adi, Davey, Jack, Barfod, Lea, Marshall, Jennifer M., Silk, Sarah E., Wright, Katherine E., Draper, Simon J., Higgins, Matthew K., Fleishman, Sarel J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293100/
https://ncbi.nlm.nih.gov/pubmed/28096331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616903114
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