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Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor

The endogenous double-stranded RNA (dsRNA) virus Leishmaniavirus (LRV1) has been implicated as a pathogenicity factor for leishmaniasis in rodent models and human disease, and associated with drug-treatment failures in Leishmania braziliensis and Leishmania guyanensis infections. Thus, methods targe...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kuhlmann, F. Matthew, Robinson, John I., Bluemling, Gregory R., Ronet, Catherine, Fasel, Nicolas, Beverley, Stephen M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293060/
https://ncbi.nlm.nih.gov/pubmed/28096399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619114114
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