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A novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13
We developed a novel murine monoclonal antibody (mAb) against the C-terminal α-helix of the human von Willebrand factor A2, designated SZ-179. We showed that SZ-179 inhibited the interactions between VWF and ADAMTS13 and prevented the degradation of high molecular weight VWF multimers. Importantly,...
Gorde:
| Argitaratua izan da: | J Hematol Oncol |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
BioMed Central
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5292787/ https://ncbi.nlm.nih.gov/pubmed/28166803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-017-0407-1 |
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