A Conformation-Sensitive Monoclonal Antibody against the A2 Domain of von Willebrand Factor Reduces Its Proteolysis by ADAMTS13

The size of von Willebrand factor (VWF), controlled by ADAMTS13-dependent proteolysis, is associated with its hemostatic activity. Many factors regulate ADAMTS13-dependent VWF proteolysis through their interaction with VWF. These include coagulation factor VIII, platelet glycoprotein 1bα, and hepari...

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Main Authors: Zhang, Jingyu, Ma, Zhenni, Dong, Ningzheng, Liu, Fang, Su, Jian, Zhao, Yiming, Shen, Fei, Wang, Anyou, Ruan, Changgeng
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2011
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133621/
https://ncbi.nlm.nih.gov/pubmed/21779388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022157
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