A recombinant chimeric plasminogen activator with high affinity for fibrin has increased thrombolytic potency in vitro and in vivo.

A recombinant plasminogen activator with high fibrin affinity and specificity was expressed by transfecting hybridoma cells with a plasmid that combines sequence coding for low molecular mass (32 kDa) single-chain urokinase-type plasminogen activator [scuPA(32kDa)] and anti-fibrin monoclonal antibod...

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Detalhes bibliográficos
Main Authors: Runge, M S, Quertermous, T, Zavodny, P J, Love, T W, Bode, C, Freitag, M, Shaw, S Y, Huang, P L, Chou, C C, Mullins, D
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC52923/
https://ncbi.nlm.nih.gov/pubmed/1946453
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