A recombinant chimeric plasminogen activator with high affinity for fibrin has increased thrombolytic potency in vitro and in vivo.

A recombinant plasminogen activator with high fibrin affinity and specificity was expressed by transfecting hybridoma cells with a plasmid that combines sequence coding for low molecular mass (32 kDa) single-chain urokinase-type plasminogen activator [scuPA(32kDa)] and anti-fibrin monoclonal antibod...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Runge, M S, Quertermous, T, Zavodny, P J, Love, T W, Bode, C, Freitag, M, Shaw, S Y, Huang, P L, Chou, C C, Mullins, D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52923/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1946453/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.22.10337
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