Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through Both Tumor Extrinsic and Intrinsic Activities

Involuntary weight loss, a part of the cachexia syndrome, is a debilitating co-morbidity of cancer and currently has no treatment options. Results from a recent clinical trial at our institution showed that biliary tract cancer patients treated with a MEK inhibitor exhibited poor tumor responses, bu...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Mol Cancer Ther
Main Authors: Talbert, Erin E., Yang, Jennifer, Mace, Thomas A., Farren, Matthew R., Farris, Alton B., Young, Gregory S., Elnaggar, Omar, Che, Zheng, Timmers, Cynthia D., Rajasekera, Priyani, Maskarinec, Jennifer M., Bloomston, Mark, Bekaii-Saab, Tanios, Guttridge, Denis C., Lesinski, Gregory B.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292063/
https://ncbi.nlm.nih.gov/pubmed/27811010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0337
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares