Antistaphylococcal Activity of WCK 771, a Tricyclic Fluoroquinolone, in Animal Infection Models

WCK 771, the arginine salt of S-(−)-nadifloxacin, was evaluated in animal models of staphylococcal infection and in vitro. For 302 methicillin-susceptible strains the MIC at which 50% of isolates are inhibited (MIC(50)) and the MIC(90) of WCK 771 were 0.03 and 0.03 μg/ml, respectively, and for 198 m...

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Bibliographische Detailangaben
Hauptverfasser: Patel, Mahesh V., De Souza, Noel J., Gupte, Shrikant V., Jafri, Mohammad A., Bhagwat, Sachin S., Chugh, Yati, Khorakiwala, Habil F., Jacobs, Michael R., Appelbaum, Peter C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Clinical Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC529196/
https://ncbi.nlm.nih.gov/pubmed/15561853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4754-4761.2004
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