The Anti-Methicillin-Resistant Staphylococcus aureus Quinolone WCK 771 Has Potent Activity against Sequentially Selected Mutants, Has a Narrow Mutant Selection Window against Quinolone-Resistant Staphylococcus aureus, and Preferentially Targets DNA Gyrase

WCK 771 is a broad-spectrum fluoroquinolone with enhanced activity against quinolone-resistant staphylococci. To understand the impact of the target-level interactions of WCK 771 on its antistaphylococcal pharmacodynamic properties, we determined the MICs for genetically defined mutants and studied...

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Main Authors: Bhagwat, Sachin S., Mundkur, Lakshmi A., Gupte, Shrikant V., Patel, Mahesh V., Khorakiwala, Habil F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
Assuntos:
Susceptibility
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635177/
https://ncbi.nlm.nih.gov/pubmed/16940059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00641-06
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