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Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia
A series of carbamate derivatives of the antileukemic sesquiterpene melampomagnolide B (MMB) has been synthesized utilizing a 1,2,4-triazole carbamate conjugate of MMB as an intermediate synthon. Five imidazole- and benzimidazole-carbamate analogs of MMB (8a-8e) were prepared and evaluated for anti-...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5291787/ https://ncbi.nlm.nih.gov/pubmed/28049618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.12.036 |
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