RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice

Thymic epithelial cells (TEC), as part of thymic stroma, provide essential growth factors/cytokines and self-antigens to support T cell development and selection. Deletion of Rb family proteins in adult thymic stroma leads to T cell hyperplasia in vivo. To determine whether deletion of Rb specifical...

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發表在:PLoS One
Main Authors: Song, Yurong, Sullivan, Teresa, Klarmann, Kimberly, Gilbert, Debra, O’Sullivan, T. Norene, Lu, Lucy, Wang, Sophie, Haines, Diana C., Van Dyke, Terry, Keller, Jonathan R.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291521/
https://ncbi.nlm.nih.gov/pubmed/28158249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171510
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