A Heterologous DNA Priming-Mycobacterium bovis BCG Boosting Immunization Strategy Using Mycobacterial Hsp70, Hsp65, and Apa Antigens Improves Protection against Tuberculosis in Mice

Tuberculosis is responsible for >2 million deaths a year, and the number of new cases is rising worldwide. DNA vaccination combined with Mycobacterium bovis bacillus Calmette Guérin (BCG) represents a potential strategy for prevention of this disease. Here, we used a heterologous prime-boost immu...

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Hlavní autoři: Ferraz, Jose C., Stavropoulos, Evangelos, Yang, Min, Coade, Steve, Espitia, Clara, Lowrie, Douglas B., Colston, M. Joseph, Tascon, Ricardo E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC529122/
https://ncbi.nlm.nih.gov/pubmed/15557616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.12.6945-6950.2004
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