Chronic Exposure to Proline Causes Aminoacidotoxicity and Impaired Beta-Cell Function: Studies In Vitro

BACKGROUND: Pancreatic islet-cell dysfunction is a hallmark in the development of diabetes, but the reasons for the primary β-cell defect are still elusive. Elevated circulating proline levels have been found in subjects with insulin resistance, obesity, and type 2 diabetes. Therefore, we assessed β...

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Détails bibliographiques
Publié dans:Rev Diabet Stud
Auteurs principaux: Liu, Zhenping, Jeppesen, Per B., Gregersen, Søren, Bach Larsen, Lotte, Hermansen, Kjeld
Format: Artigo
Langue:Inglês
Publié: SBDR - Society for Biomedical Diabetes Research 2016
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Original Data
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291183/
https://ncbi.nlm.nih.gov/pubmed/27563695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1900/RDS.2016.13.66
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