Vesicular Transport Is Not Required for the Cytoplasmic Pool of Cholera Toxin To Interact with the Stimulatory Alpha Subunit of the Heterotrimeric G Protein

Cholera toxin (CT) moves from the cell surface to the endoplasmic reticulum (ER) by retrograde vesicular transport. The catalytic A1 polypeptide of CT (CTA1) then crosses the ER membrane, enters the cytosol, ADP-ribosylates the stimulatory α subunit of the heterotrimeric G protein (Gsα) at the cytop...

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Hlavní autoři: Teter, Ken, Jobling, Michael G., Holmes, Randall K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC529108/
https://ncbi.nlm.nih.gov/pubmed/15557603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.12.6826-6835.2004
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