Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction

The evolutionarily conserved protein kinase p38 mediates innate resistance to environmental stress and microbial infection. Four p38 isoforms exist in mammals and may have been co-opted for new roles in adaptive immunity. Murine T cells deficient in p38α, the ubiquitously expressed p38 isoform, show...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hayakawa, Morisada, Hayakawa, Hiroko, Petrova, Tsvetana, Ritprajak, Patcharee, Sutavani, Ruhcha V., Jiménez-Andrade, Guillermina Yanek, Sano, Yasuyo, Choo, Min-Kyung, Seavitt, John, Venigalla, Ram K. C., Otsu, Kinya, Georgopoulos, Katia, Arthur, J. Simon C., Park, Jin Mo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290950/
https://ncbi.nlm.nih.gov/pubmed/28011639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764548
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