Bcr-Abl-Mediated Protection from Apoptosis Downstream of Mitochondrial Cytochrome c Release

Bcr-Abl, activated in chronic myelogenous leukemias, is a potent cell death inhibitor. Previous reports have shown that Bcr-Abl prevents apoptosis through inhibition of mitochondrial cytochrome c release. We report here that Bcr-Abl also inhibits caspase activation after the release of cytochrome c....

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Bibliographische Detailangaben
Hauptverfasser: Deming, Paula B., Schafer, Zachary T., Tashker, Jessica S., Potts, Malia B., Deshmukh, Mohanish, Kornbluth, Sally
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC529043/
https://ncbi.nlm.nih.gov/pubmed/15542838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.23.10289-10299.2004
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