αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin

Upon binding to the extracellular matrix protein, fibronectin, αV-class and α5β1 integrins trigger the recruitment of large protein assemblies and strengthen cell adhesion. Both integrin classes have been functionally specified, however their specific roles in immediate phases of cell attachment rem...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Bharadwaj, Mitasha, Strohmeyer, Nico, Colo, Georgina P., Helenius, Jonne, Beerenwinkel, Niko, Schiller, Herbert B., Fässler, Reinhard, Müller, Daniel J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290147/
https://ncbi.nlm.nih.gov/pubmed/28128308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14348
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