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Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication

In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, therefore appropriate regulation of centriole duplication is critical. The C. elegans homolog of Plk4, ZYG-1, is required for centriole duplication, but our understanding of how ZYG-1 levels are regulated...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Peel, Nina, Iyer, Jyoti, Naik, Anar, Dougherty, Michael P., Decker, Markus, O’Connell, Kevin F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289615/
https://ncbi.nlm.nih.gov/pubmed/28103229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006543
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